Longitudinal Changes of Cardiorespiratory Fitness Performance in High School: Association with Individual and School-Based Variables

This study aimed to model adolescents’ cardiorespiratory fitness performance change trajectories longitudinally across high school years and its relation to school- and individual/student-level factors. We employed hierarchical linear modeling to examine longitudinal cardiorespiratory fitness performance changes, as measured by the progressive aerobic capacity endurance run (PACER), over the years, between sexes, and in association with the school-level variables. Participants were 76,227 adolescents from 80 high schools in the mid-Atlantic region of the United States. School-level academic performance (SAP), the percent of students eligible for free and reduced-price meals (FARM), and physical education student-faculty ratio were obtained with permission from the school districts. The number of laps completed in PACER test improved throughout the first three years of high school, however, proportions of those within the healthy fitness zone (HFZ) decreased overall from 9th to 11th grade. Furthermore, the number of laps completed by adolescents appeared to have plateaued at 11th grade, with a significant decline during the final year of high school. Sex-based discrepancies in performance in meeting HFZ were evident, where girls significantly outperformed boys during 9th and 10th grades, and boys significantly outperformed girls during 12th grade. Additionally, SAP and FARM were positively and negatively, respectively, significantly associated with PACER performance at the school level. The odds ratio of adolescents performing in the HFZ declined significantly over the years, even though the number of PACER laps improved in the first three years. Concerted efforts should be targeted at improving cardiorespiratory fitness in high school due to its positive relationship to academic achievement in schools, and negative association with cardiovascular disease, metabolic syndrome, obesity, and all-cause mortality in adulthood

Is I-Voting I-Llegal?

The Voting Rights Act was passed to prevent racial discrimination in all voting booths. Does the existence of a racial digital divide make Internet elections for public office merely a computer geek\u27s pipe dream? Or can i-voting withstand scrutiny under the current state of the law? This i-Brief will consider the current state of the law, and whether disproportionate benefits will be enough to stop this extension of technology dead in its tracks

Malware Triage Approach using a Task Memory based on Meta-Transfer Learning Framework

To enhance the efficiency of incident response triage operations, it is not cost-effective to defend all systems equally in a complex cyber environment. Instead, prioritizing the defense of critical functionality and the most vulnerable systems is desirable. Threat intelligence is crucial for guiding Security Operations Center (SOC) analysts' focus toward specific system activity and provides the primary contextual foundation for interpreting security alerts. This paper explores novel approaches for improving incident response triage operations, including dealing with attacks and zero-day malware. This solution for rapid prioritization of different malware have been raised to formulate fast response plans to minimize socioeconomic damage from the massive growth of malware attacks in recent years, it can also be extended to other incident response. We propose a malware triage approach that can rapidly classify and prioritize different malware classes to address this concern. We utilize a pre-trained ResNet18 network based on Siamese Neural Network (SNN) to reduce the biases in weights and parameters. Furthermore, our approach incorporates external task memory to retain the task information of previously encountered examples. This helps to transfer experience to new samples and reduces computational costs, without requiring backpropagation on external memory. Evaluation results indicate that the classification aspect of our proposed method surpasses other similar classification techniques in terms of performance. This new triage strategy based on task memory with meta-learning evaluates the level of similarity matching across malware classes to identify any risky and unknown malware (e.g., zero-day attacks) so that a defense of those that support critical functionality can be conducted

Loss-of-function mutations in centrosomal protein 112 is associated with human acephalic spermatozoa phenotype.

Acephalic spermatozoa, characterized by the headless sperm in the ejaculate, is a rare type of teratozoospermia. Here, we recruited two infertile patients with an acephalic spermatozoa phenotype to investigate the genetic pathology of acephalic spermatozoa. Whole-exome sequencing analysis was performed and found mutations in CEP112 in the two patients: homozygous mutation c.496C > T:p.(Arg166X) in exon 5 from P1; and the biallelic mutations c.2074C > T:p.(Arg692Trp) in exon 20 and c.2104C > T:p.(Arg702Cys) in exon 20 from P2. Sanger sequencing confirmed the CEP112 mutations in the two patients. In silico analysis revealed that these CEP112 mutations are deleterious and rare, and all the mutations impact the coiled-coil domain of CEP112, which may affect the protein function. The c.496C > T:p.Arg166X resulted in a truncated CEP112, which was verified by the mutation expression plasmid. The CEP112 expression was significantly reduced in the P2, suggesting the biallelic mutations c.2074C > T and c.2104C > T may affect the function and stability of CEP112. Therefore, we speculate that the loss-of-function mutations in CEP112 may be account for the human acephalic spermatozoa phenotype

Livestock overgrazing disrupts the positive associations between soil biodiversity and nitrogen availability

8 páginas.- 4 figuras.- 1 tabla.- 64 referencias.- Additional supporting information may be found online in the Supporting Information sectionLivestock overgrazing influences both microbial communities and nutrient cycling in terrestrial ecosystems. However, the role of overgrazing in regulating the relationship between soil biodiversity and nitrogen availability remains largely unexplored.We performed long-term grazing exclusion experiments across eight sites along precipitation gradient covering three major types of grassland in northern China to compare the linkage between soil microbial diversity and N availability in overgrazed versus non-grazed conditions.We found a significantly positive association between fungal diversity and soil available N in non-grazed grasslands. However, the positive association was absent in overgrazed environments. Bacterial diversity is not related to soil available N in either non-grazed or overgrazed grasslands. Moreover, in bacterial community, we found a positive link between the relative abundance of Actinobacteria with soil available N in non-grazed, but not overgrazed, grasslands. Instead we found the links between relative abundance of Bacteroidetes and Acidobacteria with soil available N in overgrazed grasslands, but not non-grazed, grasslands.Synthesis. Our work provides evidence that the relationships between microbial diversity and ecosystem functions are context-dependent, and so microbial community diversity is likely not the major driver of soil N mineralization in overgrazed grasslands. Our study suggests that high intensity anthropogenic activities in grasslands restrains the capacity of diverse soil microbial communities to sustain ecosystem function, and more broadly the capacity of entire ecosystems to maintain important ecosystem processes such as plant production. Our study also indicates that the fundamental microbial communities associated with N availability change with differing land management strategies (e.g. livestock grazing).National Natural Science Foundation of China, Grant/Award Number: 31772652, U1603235, 31660679 and 31770500; National Key Research and Development Program of China, Grant/Award Number: 2016YFC0500602; Program for Introducing Talents to Universities, Grant/Award Number: B16011; Ministry of Education Innovation Team Development Plan, Grant/Award Number: 2013-373; Innovative Team of Grassland Resources from the Ministry of Education of China, Grant/Award Number: IRT_17R59; Horizon 2020 Framework Program, Grant/Award Number: H2020-MSCA-IF-2016Peer reviewe

Effects of livestock overgrazing on the relationships between plant and microbial diversity across the temperate steppes in northern China

11 páginas.- 3 figuras.- 3 tablas.- 57 referencias.-Livestock overgrazing has led to worldwide grassland degradation, posing a significant threat to plant and soil microbial diversity. However, little is known about whether livestock overgrazing influences plant and soil microbial diversity linkages. We examined relationships between plant and soil microbial beta diversity in eight pairs of ungrazed and overgrazed sites across temperate steppes in northern China. Our results revealed a positive correlation between plant and microbial beta diversity across ungrazed grasslands, and overgrazing did not change this relationship. However, different mechanisms underlay the correlations between plant and microbial beta diversity in ungrazed and overgrazed grasslands. In ungrazed grasslands, plant and microbial diversity associations were maintained mainly due to their similar responses to the shared environmental factors. While in overgrazed grasslands, the maintenance of plant and microbial diversity associations was primarily due to their functional associations. Furthermore, the positive links between plant species and microbial taxa increased in overgrazed grasslands, indicating that more soil microbial taxa form close associations with plant species in overgrazed grasslands. Our work provides new insights regarding the mechanisms of plant and microbial communities that associate under different ecological contexts, ultimately suggesting that the functional associations of plant and microbial communities are tighter as grazing intensifies in grasslands.The work was made possible by the National Natural Science Founda-tion of China (No. 32271642, 32061143027). M.D-B. acknowledges support from the Spanish Ministry of Science and Innovation for the I+D+i project PID2020-115813RA-I00 funded by MCIN/AEI/10.13039/501100011033. M.D-B. is also supported by a project of the Fondo Europeo de Desarrollo Regional (FEDER) and the Consejería de Transformación Económica, Industria, Conocimiento y Universidades of the Junta de Andalucía (FEDER Andalucía 2014-2020 Objetivo temático“01 - Refuerzo de la investigación, el desarrollo tecnológico y la innovación”) associated with the research project P20_00879 (ANDABIOMA).Peer reviewe

The importance of NOx control for peak ozone mitigation based on a sensitivity study using CMAQ‐HDDM‐3D model during a typical episode over the Yangtze River delta region, China.

In recent years, ground-level ozone (O3) has been one of the main pollutants hindering air quality compliance in China's large city-clusters including the Yangtze River Delta (YRD) region. In this work, we utilized the process analysis (PA) and the higher-order decoupled direct method (HDDM-3D) tools embedded in the Community Multiscale Air Quality model (CMAQ) to characterize O3 formation and sensitivities to precursors during a typical O3 pollution episode over the YRD region in July 2018. Results indicate that gas-phase chemistry contributed dominantly to the ground-level O3 although a significant proportion was chemically produced at the middle and upper boundary layer before reaching the surface via diffusion process. Further analysis of the chemical pathways of O3 and Ox formation provided deep insights into the sensitivities of O3 to its precursors that were consistent with the HDDM results. The first-order sensitivities of O3 to anthropogenic volatile organic compounds (AVOC) were mainly positive but small, and temporal variations were negligible compared with those to NOx. During the peak O3 time in the afternoon, the first- and second-order sensitivities of O3 to NOx were significantly positive and negative, respectively, suggesting a convex response of O3 to NOx over most areas including Shanghai, Hangzhou, Nanjing and Hefei. These findings further highlighted an accelerated decrease in ground-level O3 in the afternoon corresponding to continuous decrease of NOx emissions in the afternoon. Therefore, over the YRD region including its metropolises, NOx emission reductions will be more important in reducing the afternoon peak O3 concentration compared with the effect of VOC emission control alone

Nursing intervention for osteoporosis patients : A literature review

It is estimated that over 200 million people worldwide have osteoporosis. The prevalence of osteoporosis is continuing to escalate with the increasingly elderly patients. The aim of this study was to conduct a literature review to find out nursing intervention to prevent osteoporosis.   The study was conducted as a literature review and the data was collected using two databases: CINAHL and PubMed. Results from six articles were analyzed using inductive content analysis method, through which five main categories emerged; 1. different nursing interventions for osteoporosis patients 2. Patients’ educations 3. Appropriate nursing diagnoses 4. Patients’ self-care and 5. Physical exercise for patients  In conclusion, Nursing interventions can reduce the incidence of osteoporosis, accelerate the recovery of osteoporosis, and reduce the risk of osteoporosis. Also, exercise and nutrition influenced osteoporosis patients’ bone density at best in the categories analyzed within this review. However, these nursing interventions has a far wider scope of impact that needs to be explored. Further research is recommended to study the nursing interventions for the different ages of osteoporosis patients and all kinds of ways to protect the patients from fracture. Regularly exercise and supplement vitamins and calcium could be studied as an evidence-based option in supportive treatment. Patients education could be further explored as an intervention to study it is influence on patients’ condition to protect themselves.